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Six Nations round three: Manu Tuilagi and Louis Rees-Zammit out for England and Wales, Rory Darge starts for Scotland against France

Manu Tuilagi will miss England’s clash with Wales at Twickenham after sustaining a hamstring injury in training, whilst Gloucester’s Louis Rees-Zammit has been dropped by Wales.

Tuilagi’s replacement in the England starting team on Saturday will be confirmed on the day, with Joe Marchant recalled to the squad.

Courtney Lawes will resume captaincy duties for England after recovering from an inner ear issue, taking over from Tom Curry.

Meanwhile, Rees-Zammit has been dropped in favour of Josh Adams as the starting wing for Wales, with Taulupe Faletau returning to the back row, replacing Jac Morgan.

Both England and Wales have won one game and lost one game so far in this campaign, with France the only team that are an unbeaten so far, after seeing off both Italy and Ireland.

Scotland will be hoping to change that status as they host Les Bleus at BT Murrayfield on Saturday, looking to their opening round win over England as inspiration.

Glasgow flanker Rory Darge will make his first start for the Scots, whilst Zander Fagerson will start at tight-head prop ahead of WP Nel, who drops to the bench.

Ireland have heavily rotated ahead of their match against perennial wooden-spoon contenders Italy, but there’s also a welcome return to the bench for Johnny Sexton, who declared himself fit after a hamstring issue.

23-year-old Michael Lowry will make his debut at full back, replacing Hugo Keenan.

Stay up to date with all of the day’s sporting news here.

Scotland vs France – BT Murrayfield, 2.15pm

Scotland

IN: Zander Fagerson, Magnus Bradbury, Rory Darge

OUT: Matt Fagerson, WP Nel, Jonny Gray

XV: Schoeman, McInally, Z. Fagerson, Skinner, Gilchrist (VC), Darge, Watson, Bradbury, Price, Russell (VC), Van Der Merwe, Tuipulotu, Harris, Graham, Hogg (C)

Replacements: Turner, Kebble, Nel, Hodgson, Haining, White, Kinghorn, Bennett

France

IN: Jonathan Danty

OUT: Gabin Villière 

XV: Baille, Marchand, Atonio, Woki, Willemse, Cros, Alldritt, Jelonch, Dupont, Ntamack (C), Moefana, Danty, Fickou, Penaud, Jaminet

Replacements: Mauvaka, Gros, Bamba, Taofifenua, Flament, Cretin, Lucu, Ramos

England vs Wales – Twickenham, 4:45pm

England

IN: Luke Cowan-Dickie, Kyle Sinckler, Courtney Lawes

OUT: Jamie George, Will Stuart, Nick Isiekwe

XV: Genge, Cowan-Dickie, Sinckler, Ewels, Itoje, Lawes (C), Curry, Dombrandt, Randall, Smith, Nowell, Tuilagi*, Slade, Malins, Steward

Replacements: George, Marler, Stuart, Isiekwe, Simmonds, Youngs, Ford, Daly

*Tuilagi ruled out (hamstring), replacement tbc on Saturday.

Wales

IN: Tuilupe Faletau, Josh Adams

OUT: Jac Morgan, Louis Rees-Zammit

XV: Jones, Elias, Francis, Rowlands, Beard (VC), Moriarty, Basham, Faletau, Williams, Biggar (C), Adams, Tompkins, Watkin, Cuthbert, Williams

Replacements: Lake, Thomas, Brown, S. Davies, Morgan, Hardy, Anscombe, J. Davies

Ireland vs Italy – Aviva Stadium, 3pm

Ireland

IN: Dan Sheehan, Ryan Baird, Peter O’Mahony, Robbie Henshaw, James Lowe, Michael Lowry

OUT: Ronan Kelleher, James Ryan, Jack Conan, Bundi Aki, Hugo Keenan, Andrew Conway

XV: Porter, Sheehan, Furlong, Beirne, Baird, O’Mahony (C), Van Der Flier, Doris, Gibson Park, Carbery, Lowe, Henshaw, Ringrose, Hansen, Lowry

Replacements: Herring, Kilcoyne, Bealham, Treadwell, Conan, Casey, Sexton, Hume

Italy

IN: Giovanni Pettinelli, Leonardo Marin, Pierre Bruno

OUT: Braam Steyn, Marco Zanon, Federico Mori

XV: Fischetti, Lucchesi, Ceccarelli, Cannone, Ruzza, Pettinelli, Lamaro (C), Halafihi, Varney, Garbisi, Ioane, Marin, Brex, Bruno, Padovani

Replacements: Faiva, Nemer, Pasquali, Sisi, Zuliani, Steyn, Fusco, Zanon

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